SELECT A RECEPTOR in the table and click a green button

The next page shows ligands preferring a transducer or effector family (e.g. G protein, arrestin, GRK, ERK etc.).
Physiology-bias, pathway-bias and benchmark-bias is explained in the article Community Guidelines for GPCR Ligand Bias.
*Biased ligands have a bias factor ≥ 5.

  Receptor classification Number of ligands


Class
 		 Ligand type
 		 Family
 		 Species
 		 Receptor
(UniProt)		 Receptor
(GtP)		 Tested
(total)
A Aminergic 5-Hydroxytryptamine Homo sapiens 5HT1A 5-HT1A 24
A Aminergic 5-Hydroxytryptamine Homo sapiens 5HT1B 5-HT1B 12
A Aminergic 5-Hydroxytryptamine Homo sapiens 5HT2A 5-HT2A 11
A Aminergic 5-Hydroxytryptamine Homo sapiens 5HT2B 5-HT2B 20
A Aminergic 5-Hydroxytryptamine Homo sapiens 5HT2C 5-HT2C 32
A Aminergic 5-Hydroxytryptamine Homo sapiens 5HT7R 5-HT7 6
A Aminergic Acetylcholine (muscarinic) Homo sapiens ACM1 M1 14
A Aminergic Acetylcholine (muscarinic) Homo sapiens ACM2 M2 22
A Aminergic Dopamine Homo sapiens DRD2 D2 319
A Aminergic Acetylcholine (muscarinic) Homo sapiens ACM3 M3 8
A Aminergic Acetylcholine (muscarinic) Homo sapiens ACM4 M4 5
A Aminergic Acetylcholine (muscarinic) Homo sapiens ACM5 M5 5
A Aminergic Adrenoceptors Homo sapiens ADA1A α1A-adrenoceptor 8
A Aminergic Adrenoceptors Homo sapiens ADA2C α2C-adrenoceptor 8
A Aminergic Adrenoceptors Homo sapiens ADRB1 β1-adrenoceptor 25
A Aminergic Adrenoceptors Homo sapiens ADRB2 β2-adrenoceptor 67
A Aminergic Dopamine Homo sapiens DRD1 D1 129
A Aminergic Dopamine Homo sapiens DRD3 D3 28
A Aminergic Dopamine Homo sapiens DRD5 D5 6
A Aminergic Histamine Homo sapiens HRH3 H3 5
A Aminergic Histamine Homo sapiens HRH4 H4 31
A Peptide Angiotensin Homo sapiens AGTR1 AT1 27
A Peptide Apelin Homo sapiens APJ apelin 54
A Peptide Complement peptide Homo sapiens C5AR1 C5a1 2
A Peptide Endothelin Homo sapiens EDNRA ETA 4
A Peptide Formylpeptide Homo sapiens FPR1 FPR1 13
A Peptide Formylpeptide Homo sapiens FPR2 FPR2/ALX 6
A Peptide Galanin Homo sapiens GALR2 GAL2 3
A Peptide Ghrelin Homo sapiens GHSR ghrelin 17
A Peptide Melanocortin Homo sapiens MSHR MC1 4
A Peptide Melanocortin Homo sapiens MC3R MC3 4
A Peptide Melanocortin Homo sapiens MC4R MC4 4
A Peptide Melanocortin Homo sapiens MC5R MC5 4
A Peptide Neuropeptide S Homo sapiens NPSR1 NPS 6
A Peptide Neuropeptide Y Homo sapiens NPY1R Y1 4
A Peptide Opioid Homo sapiens OPRD δ 82
A Peptide Opioid Homo sapiens OPRK κ 123
A Peptide Opioid Homo sapiens OPRM μ 310
A Peptide Opioid Homo sapiens OPRX NOP 28
A Peptide Proteinase-activated Homo sapiens PAR2 PAR2 2
A Peptide Relaxin family peptide Homo sapiens RXFP1 RXFP1 2
A Peptide Vasopressin and oxytocin Homo sapiens V1AR V1A 2
A Peptide Vasopressin and oxytocin Homo sapiens V1BR V1B 2
A Peptide Vasopressin and oxytocin Homo sapiens V2R V2 2
A Peptide Vasopressin and oxytocin Homo sapiens OXYR OT 2
A Protein Chemokine Homo sapiens CCR1 CCR1 11
A Protein Chemokine Homo sapiens CCR2 CCR2 3
A Protein Chemokine Homo sapiens CCR5 CCR5 7
A Protein Chemokine Homo sapiens CCR10 CCR10 2
A Protein Chemokine Homo sapiens CXCR1 CXCR1 3
A Protein Chemokine Homo sapiens CXCR2 CXCR2 6
A Protein Chemokine Homo sapiens CXCR3 CXCR3 33
A Protein Chemokine Homo sapiens CXCR4 CXCR4 2
A Protein Glycoprotein hormone Homo sapiens LSHR LH 4
A Lipid Free fatty acid Homo sapiens FFAR1 FFA1 9
A Lipid Lysophospholipid (LPA) Homo sapiens LPAR1 LPA1 10
A Lipid Lysophospholipid (S1P) Homo sapiens S1PR1 S1P1 2
A Lipid Cannabinoid Homo sapiens CNR1 CB1 48
A Lipid Cannabinoid Homo sapiens CNR2 CB2 46
A Lipid Prostanoid Homo sapiens PE2R2 EP2 39
A Lipid Prostanoid Homo sapiens PE2R4 EP4 11
A Nucleotide Adenosine Homo sapiens AA1R A1 34
A Nucleotide Adenosine Homo sapiens AA2BR A2B 11
A Nucleotide Adenosine Homo sapiens AA3R A3 55
A Orphan A orphans Homo sapiens GPR84 GPR84 77
B1 Peptide Calcitonin Homo sapiens CALCR CT 8
B1 Peptide Calcitonin Homo sapiens CALRL calcitonin -like 19
B1 Peptide Glucagon Homo sapiens GLP1R GLP-1 60
B1 Peptide Glucagon Homo sapiens GLR glucagon 1
A Peptide Opioid Rattus norvegicus OPRD δ 16
A Lipid Cannabinoid Mus musculus CNR2 CB2 39
A Aminergic 5-Hydroxytryptamine Rattus norvegicus 5HT2A 5-HT2A 11
B1 Peptide Glucagon Mus musculus GLP1R GLP-1 7
A Peptide Opioid Mus musculus OPRD δ 42
A Peptide Opioid Rattus norvegicus OPRM μ 24
A Peptide Opioid Mus musculus OPRK κ 43
A Aminergic Dopamine Mus musculus DRD2 D2 21
A Nucleotide Adenosine Mus musculus AA2BR A2B 8
B1 Peptide Glucagon Rattus norvegicus GLP1R GLP-1 17
C Ion Calcium-sensing Rattus norvegicus CASR CaS 10
A Peptide Opioid Mus musculus OPRM μ 43
A Peptide Opioid Canis lupus familiaris A0A0F6TMT6 μ 1